A carefully balanced blend of plant extracts rich in polyphenols, complemented by niacin, zinc, vitamin C and vitamin D.
BENEFITS OF DAILY USE
Balanced plant extracts, vitamins and minerals
Niacin contributes to normal energy‑yielding metabolism
Zinc contributes to the maintenance of normal skin, hair and nails
Zinc has a role in the process of cell division
Vitamin C contributes to the protection of cells from oxidative stress
Vitamin D contributes to the normal function of the immune system
Contents: 30 bottles à 25 ml
Consumption information: Consume the contents of one bottle once a day in the morning or at noon before eating. Shake well before drinking.
Each plant extract is rich in natural polyphenols.
Rich in polyphenols and adds a fruity note.
Mango kernel extract can:
A traditional plant extract with a mild herbal taste.
Olive leaf extract can:
Contains naturally occurring polyphenols.
Apple extract can:
Provides a berry flavour and polyphenols.
Blueberry extract can:
Contains glucosinolates, naturally occurring plant compounds.
Sulforaphane can:
Make SIRTFOOD® SHOT part of your morning routine.
Activate the potent blend of natural extracts by giving the bottle a good shake.
Enjoy the delicious, powerful shot in one go. Best consumed in the morning.
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Enjoy the taste.
This is how it works!
The sirtuin genes and the resulting sirtuin enzymes are activated when there is a lack of energy. Classically, this is achieved by calorie restriction (diet), fasting and exercise. An alternative to achieve this activation is the intake of so-called sirtfoods. These foods contain special substances called sirtuin activators.
Sirtfoods are first and foremost plant-based food items. Plants build secondary substances such as polyphenols. These act on the sirtuins and simulate the signal of a lack of energy normally caused by fasting, dieting and exercise.
Active sirtuins then switch on protective genes and switch off dangerous genes. Studies show that the activation of sirtuin genes can prolong life. In countries like Japan and India, various Sirtfoods are part of the daily diet. Also known as 'blue zones', they have the lowest incidence of lifestyle associated diseases such as hypertension, obesity, diabetes, fatty liver and cancer. Sirtfoods are especially rich in polyphenols.
The Science Behind Them
In 2003, biologist David Sinclair discovered the Sir2 gene in yeast fungi. He found that the Sir2 became active when food was scarce. Despite a lack of energy, this led to the survival of the yeasts. Furthermore, the Sir2 gene was detected in all living beings and was known as the enzyme group of sirtuins through further research.
Humans possess a total of seven sirtuins. Sirtuins are also called SIRT (silent mating type information regulation 2 homolog). They also act as energy sensors in our cells and are activated in the same way as in the yeasts when there is a lack of energy.
Thanks to their properties, sirtuins are multifunctional and regulate many metabolic processes as well as the aging process.
SIRT1 is predominantly located in the nucleus, and also in the cytosol. SIRT2 is localized in the cytosol. SIRT3, SIRT4, and SIRT5 are mitochondrial proteins, but SIRT3 may also be found in the nucleus and cytosol under different cellular events. SIRT6 and SIRT7 are localized in the nucleus and nucleolus, respectively. [1]
The graphic shows a protein that is used by the research group headed by Prof. Dr. med. Clemens Steegborn has identified as Sirt1 substrate. It is a DNA binding protein, the DNA is orange. The deacetylation site is the single gray strand on the top right. Graphic: Prof. Dr. med. Clemens Steegborn; free for publication.
When energy is scarce, cells activate maintenance pathways regulated by sirtuins. These enzymes help cells adapt to low‑energy conditions by modifying proteins and influencing gene expression.
Sirtuins are deacetylases that remove acetyl groups from histones and other proteins. In the nucleus they promote tighter DNA packaging, which reduces gene accessibility and modulates gene expression.
Switching gene sections on and off.
DNA methylation is the attachment of methyl groups to certain nucleotides of DNA. The DNA contains the bases adenine (A), cytosine (C), guanine (G) and thymine (T). These bases together encode the genetic fingerprint of an organism.
A gene can be deactivated by finding methylated cytosines in its vicinity. This phenomenon prevents all genes in a tissue or cell from being copied simultaneously due to methylated cytosines acting as gene switches. In addition, special methylation patterns are formed which can be used as early markers of diseases or to determine the biological cell age.
Enzymes that attach methyl groups to the DNA, which are required for metabolism and DNA repair, are also proteins that can be activated or deactivated by sirtuins through the cleavage of acetyl groups. These enzymes play a role, for example Alzheimer's disease, Parkinson's disease, diabetes mellitus and obesity.
Schematic representation of DNA methylation and histone packaging as the main epigenetic re- gulators of gene activation. If methyl groups are added at the gene's starting point (promoter), the gene is blocked for activation. Vice versa, if the promoter is accessible, the gene can be activated and hence, gene products like e.g. proteins can be produced. DNA is also protected from activation if the histones, around which the DNA is wrapped, are located closely next to each other. If the packaging is loosened, genes become accessible. [4]
Micro RNAs are tiny pieces of RNA that can also immobilise genes and serve, among other things, for communication between cells and different tissues. They are important biomarkers for very current events in the body. At the same time the activity of sirtuin genes is controlled by micro RNAs.
More precisely, gene copies (messenger RNA) of Sirtuin 1, for example, which are formed in the cell nucleus, can be inactivated by a special micro RNA (miR-34a).
In concrete terms, the epigenetic regulation of DNA is disturbed by the aging process and by overweight.
However, it is important to know that the modulation of sirtuin activity, through the intake of sirtfoods in sufficient quantity, can lead to such changes being positively influenced.
Explore key studies and download the PDFs.
Choose the supply that suits your routine.
